FDRdb

FDRdb consolidates curated associations between Ribonucleic Acids (RNAs) and fibrotic diseases and aggregates high-throughput datasets and analysis tools to study RNA deregulation in organ fibrosis.

Key Features:

• Extensive Data Collection: 1,947 associations between 912 RNAs and 92 distinct fibrotic diseases across eight species are catalogued.
• High-Throughput Dataset Repository: Aggregates metadata and entries from 764 high-throughput datasets relevant to fibrotic diseases.
• Analytical Tools: Provides functionality for analysis of expression profiles, including differential expression analysis and pathway enrichment studies.

Scientific Applications:

• Biomarker and target discovery: Identification of RNAs associated with fibrosis for potential biomarkers and therapeutic targets.
• Comparative analysis and validation: Use of aggregated high-throughput datasets to validate findings and perform comparative studies across experiments.
• Cross-species pathway exploration: Examination of similarities and differences in fibrotic pathways across eight species represented in the database.

Methodology:

Manual curation of literature-derived RNA–fibrosis associations, aggregation of 764 high-throughput datasets, and integration of analytical tools enabling differential expression analysis and pathway enrichment studies.