FerrDb

FerrDb curates literature-derived annotations of ferroptosis regulators, biomarkers, and disease associations to support research into ferroptosis mechanisms and their links to human diseases.

Key Features:

• Literature curation: Comprehensive manual curation from 784 PubMed articles.
• Regulators: Catalogs 253 ferroptosis regulators annotated as drivers (108), suppressors (69), inducers (35), and inhibitors (41).
• Biomarkers: Contains 111 ferroptosis biomarkers.
• Disease associations: Records 95 associations between ferroptosis and human diseases.
• Manual curation: First manually curated database dedicated to ferroptosis.
• Update frequency: Undergoes biannual updates.

Scientific Applications:

• Mechanistic studies: Supports investigation of ferroptosis mechanisms via curated regulators and markers.
• Disease association studies: Enables exploration of links between ferroptosis and human diseases, including cancers and degenerative conditions.
• Biomarker research: Provides a curated set of biomarkers for studies of ferroptosis-related diagnostic and mechanistic markers.

Methodology:

Manual curation with systematic extraction and annotation of ferroptosis regulators, markers, and disease associations from 784 PubMed articles.