FifBase

FifBase consolidates fertility-associated genetic and environmental factors across domestic animal species to support research on genetic and environmental determinants of reproduction.

Key Features:

• Extensive literature curation: Integrates data from 3,301 PubMed articles covering 13 animal species and identifies 2,823 genes associated with 75 fertility indicators or 47 environmental factors.
• Gene integration from multiple sources: Includes a comprehensive list of 1,558 fertility-linked genes across ten species derived from RNA-Seq datasets (1,088 genes) and text mining data (470 genes).
• Fertility–gene and fertility–environment mappings: Catalogs 2,910 fertility-gene pairs and 58 fertility–environmental factor associations for detailed relationship analysis.

Scientific Applications:

• Reproductive biology research: Provides a centralized repository of fertility-associated genes and environmental factors for studies of reproductive function in domestic animals.
• Genetic studies and breeding: Supports identification of fertility-related genes from omics datasets to inform genetic studies and animal breeding programs.
• Environmental impact analysis: Enables investigation of how environmental factors influence fertility to inform mitigation strategies.

Methodology:

Data were compiled by manual curation of published literature, text mining of articles, and analysis of RNA-Seq datasets.