FINDbase

FINDbase records frequencies of causative genetic variations across global populations to support research into inherited disorders and pharmacogenomics.

Key Features:

• Global Data Coverage: Compiles genetic variation frequency data linked to disorder name, related gene, and geographical or ethnic context across diverse populations and ethnic groups worldwide.
• Pharmacogenomic Markers: Provides allele frequencies for 144 pharmacogenomic markers across 14 genes covering 150 populations and ethnic groups relevant to drug metabolism and transport.
• Data Querying and Visualization: Implements querying and visualization using Microsoft's PivotViewer built on Silverlight for exploration and visualization of dataset results.

Scientific Applications:

• Population Genetics: Characterizes population-specific frequencies of causative variants and allele distributions across ethnic groups.
• Pharmacogenomics: Assesses population allele frequencies of pharmacogenomic markers to inform studies of drug metabolism and transport genes.
• Medical Genetics of Inherited Disorders: Enables comparison of causative variant frequencies across populations to support analyses of genetic risk factor prevalence for inherited disorders.

Methodology:

Compilation of genetic variation frequency records from diverse sources, regular database updates, and integration of querying and visualization via Microsoft's PivotViewer (Silverlight).