FishmiRNA

FishmiRNA provides manually curated, evolutionarily supported miRNA annotations and integrated expression profiles for ray-finned fishes to support comparative and functional analyses of miRNA genes and their mature products.

Key Features:

• Manually Curated Annotations: High-quality, manually curated annotations of miRNA genes and their mature products across ray-finned fish species.
• Orthology Relationships: Orthology among miRNA genes established using sequence similarity and conserved syntenies.
• Expression Data Integration: Expression profiles are provided for each detected mature miRNA across species and organs.
• Evolutionary Support: Annotations are supported by evolutionary conservation across ray-finned fishes to facilitate comparative analyses.

Scientific Applications:

• Post-transcriptional Gene Regulation: Study miRNA-mediated regulation of gene expression in ray-finned fishes using annotated miRNAs and expression profiles.
• Comparative and Evolutionary Genomics: Identify conserved miRNAs and infer evolutionary relationships of miRNA genes across species.
• Functional Genomics: Correlate miRNA expression patterns across organs and species to investigate potential functional roles.
• Developmental Biology: Examine conserved miRNAs relevant to developmental processes in ray-finned fishes.

Methodology:

Manual curation of miRNA annotations; orthology inference based on sequence similarity and conserved syntenies; integration of expression data for detected mature miRNAs across species and organs.