FIVEx

FIVEx provides interactive visualization and functional interpretation of expression quantitative trait loci (eQTLs) across multiple human tissues to elucidate tissue-specific regulatory effects of genetic variants.

Key Features:

• Multi-tissue eQTL visualization: Visualizes eQTL associations across multiple human tissues to compare variant–gene expression relationships.
• Functional interpretation of trait-associated variants: Provides tissue- and locus-specific annotations linking genetic variants to effects on gene expression.
• Integration with GTEx v8: Utilizes the GTEx v8 dataset as the reference multi-tissue transcriptomic resource for analyses.
• Population-scale multi-tissue profiles: Supports exploration of population-scale multi-tissue transcriptomic data to investigate regulatory mechanisms.

Scientific Applications:

• Interpretation of disease- or trait-associated variants: Assesses how variants influence gene expression across tissues to aid variant prioritization.
• Mapping tissue-specific regulatory mechanisms: Identifies tissues where genetic variants exert regulatory effects on gene expression.
• Prioritization of candidate targets: Aids selection of genes or loci for follow-up as potential therapeutic targets based on tissue-specific expression effects.

Methodology:

Visualizes and functionally interprets multi-dimensional eQTL data derived from the GTEx v8 multi-tissue transcriptomic dataset.