flashfm-ivis

flashfm-ivis visualizes and compares fine-mapping results to identify potential causal genetic variants across single- and multi-trait quantitative trait analyses.

Key Features:

• Interactive visualization plots: Provides interactive plots for exploring variant-level fine-mapping results across multiple traits.
• Network diagrams: Generates network diagrams that illustrate joint effects between variants across different traits.
• Regional association plots: Integrates fine-mapping results into regional association plots to display variant associations within specific genomic regions.
• Single- and multi-trait comparison: Compares outputs from single-trait and multi-trait fine-mapping analyses to identify shared or distinct causal variants.

Scientific Applications:

• Fine-mapping of quantitative traits: Supports localization of putative causal variants underlying variation in quantitative traits.
• Comparative trait analysis: Enables identification of shared genetic influences and trait-specific associations through comparison of single- and multi-trait results.

Methodology:

Compares single-trait and multi-trait fine-mapping outputs, constructs network diagrams of joint variant effects across traits, and overlays fine-mapping results on regional association plots.