FluGenome

FluGenome analyzes influenza A virus genomes to detect reassortment and assign lineages and genotypes using a standardized genotype nomenclature.

Key Features:

• Nomenclature System: Implements a comprehensive genotype nomenclature to systematically describe gene segment reassortments in influenza A viruses.
• Eight RNA Segment Analysis: Analyzes the eight RNA segments of the influenza A virus genome to characterize segment origins.
• Reassortment Detection: Algorithms automatically detect reassortment events among gene segments.
• Lineage and Genotype Assignment: Assigns lineages and genotypes based on the nomenclature system to enable tracking of evolutionary changes across hosts.

Scientific Applications:

• Understanding Viral Evolution: Provides lineage and genotype data to study how genetic reassortment contributes to influenza A virus evolution.
• Host Range Analysis: Enables detection of genotype differences attributable to reassortment events to investigate host range shifts between avian and mammalian species.
• Virulence and Transmissibility Studies: Supports analysis of how genetic variation from reassortment may influence virulence and transmissibility of influenza A viruses.

Methodology:

Analyzes the eight RNA segments of the influenza A virus genome; algorithms automatically detect reassortment events and assign lineages and genotypes according to the nomenclature system.