flumut

flumut identifies molecular markers in Influenza A(H5N1) nucleotide sequences to support genomic surveillance of mutations affecting host adaptation, virulence, and antiviral resistance.

Key Features:

• Molecular Marker Identification: Detects molecular markers associated with host adaptation, increased virulence, and antiviral resistance in H5N1 genomes.
• Sequence Input: Analyzes complete or partial nucleotide sequences of Influenza A(H5N1).
• Database Integration: Compares sequences against the curated FluMutDB to enable rapid analysis of thousands of nucleotide sequences.
• Comprehensive Outputs: Generates tabular outputs listing detected molecular markers, their reported biological effects, and literature references.

Scientific Applications:

• Genomic Surveillance: Enables monitoring of H5N1 viral evolution through detection of recurrent and novel mutations.
• Pandemic Risk Assessment: Identifies mutations that may signal increased pandemic potential by altering host range or virulence.
• Resistance and Adaptation Monitoring: Tracks genetic changes associated with antiviral resistance and host adaptation to inform public-health responses.

Methodology:

flumut uses computational algorithms to analyze nucleotide sequences and compares them against the curated FluMutDB to pinpoint mutations linked to phenotypic traits such as host adaptation, virulence, and antiviral resistance.