Flype

Flype performs integrated management, secondary and tertiary analysis, annotation, and delivery of next-generation sequencing (NGS) genomic results to support clinical interpretation and EHR integration.

Key Features:

• Data Integration: Securely accepts NGS data from diverse sources and handles large datasets.
• Order Management: Sends and routes orders to external destinations.
• Secondary Analysis and Annotation: Performs comprehensive secondary analysis and variant annotation of NGS data.
• Central Repository: Maintains a centralized repository of genomic variants for organized storage and retrieval.
• Tertiary Analysis and Clinical Interpretation: Supports tertiary analysis and clinical interpretation of variants.
• EHR Integration: Sends signed-out data to EHR systems as PDF documents and as discrete data elements.
• Population Frequency Analysis: Enables population frequency analysis of variants.
• Dynamic Annotation Updates: Updates variant annotations as new literature emerges.

Scientific Applications:

• In-house NGS and PGX testing: Supports in-house NGS tests and pharmacogenomics (PGX) testing workflows.
• External laboratory scale-up: Facilitates scaling of genomic testing through collaboration with external laboratories.
• Consumer genomics integration: Integrates consumer genomics data from two external partners.
• Reporting: Generates various reporting outputs for clinical and analytical use.

Methodology:

Computational steps explicitly include secure ingestion of NGS data, secondary analysis and annotation, maintenance of a centralized variant repository, population frequency analysis, dynamic annotation updates, tertiary analysis and clinical interpretation, transmission of signed-out results to EHRs as PDF and discrete data elements, and routing of orders to external destinations.