FNV

FNV renders vector graphic visualizations of small- to moderate-sized biological networks and pathways representing genes, proteins, mRNAs, microRNAs, metabolites, regulatory DNA elements, diseases, viruses, and drugs.

Key Features:

• XML input format: Accepts biological network data formatted in Extensible Markup Language (XML) to represent relationships among genes, proteins, mRNAs, microRNAs, metabolites, regulatory DNA elements, diseases, viruses, and drugs.
• Vector graphics rendering (Adobe ActionScript 3.0): Renders network diagrams as scalable vector graphics using Adobe ActionScript 3.0 for web embedding.
• Flexible layout options: Provides flexible layout options for presenting network diagrams.
• Integration with web-based systems: Has been integrated as a component in Genes2Networks, Lists2Networks, KEA (KEGG Enrichment Analysis), ChEA (ChIP-Enrichment Analysis), and PathwayGenerator.
• PDF embedding: Embeds pathway visualizations directly into PDF files.

Scientific Applications:

• Gene–protein interaction analysis: Visualizes and supports analysis of gene–protein interaction networks and their implications in disease contexts.
• Regulatory mechanism exploration: Enables exploration of regulatory mechanisms involving microRNAs and other regulatory DNA elements.
• Drug–gene interaction investigation: Facilitates investigation of drug–gene interactions and potential therapeutic targets.
• Pathway presentation for publications: Produces publication-ready pathway diagrams embeddable in PDF documents for communication of network-based findings.

Methodology:

Biological data are converted into XML, which the viewer processes and renders as vector graphics via Adobe ActionScript 3.0.