FOBI

FOBI integrates food intake data and metabolomic biomarkers within an ontological framework to standardize, annotate, and enable analysis of nutrition and metabolomics datasets.

Key Features:

• Hierarchical Structure: FOBI employs a hierarchical ontology organizing food entities and associated metabolite biomarkers for detailed categorization and relationship mapping.
• Food Ontology: The Food Ontology represents raw foods and multi-component foods to support diverse nutritional classifications.
• Biomarker Ontology: The Biomarker Ontology classifies food intake biomarkers by chemical classes to enable precise metabolite identification.
• Formal Naming System and Relations: FOBI defines formal names, properties, and relations between foods and biomarkers to ensure consistent annotation.
• Bidirectional Visualization: The ontology supports bidirectional navigation between metabolomics data and nutritional information to aid interpretation.
• Metabolomics Workflow Reporting: FOBI provides structures to standardize reporting of metabolite identification and experimental design.
• Enrichment Analysis Support: FOBI supports enrichment analysis approaches for nutrimetabolomic data.
• Serialization Formats: FOBI is available in OWL and OBO formats.

Scientific Applications:

• Annotation and Standardization: FOBI facilitates consistent annotation of foods and biomarkers using a defined nomenclature across studies.
• Metabolomics Workflow Reporting: FOBI standardizes reporting of metabolite identification and experimental design to improve reproducibility and data sharing.
• Enrichment Analysis: FOBI enables enrichment analyses of nutrimetabolomic datasets to identify dietary patterns and associated metabolic impacts.
• Integrative Analysis: FOBI supports integration of dietary self-reporting and metabolomics measurements for combined analysis.

Methodology:

FOBI integrates dietary self-reporting and metabolomics data within a hierarchical, interconnected ontology that links food entities to metabolite biomarkers.