FOG

FOG maps and annotates newly discovered genomic features onto the latest version of the human reference genome to integrate diverse feature types such as microRNAs (miRNAs), microarray primers or probes, Chip-on-Chip data, CpG islands, and single nucleotide polymorphisms (SNPs) for downstream genomic analyses.

Key Features:

• Automated Mapping: Automates the process of aligning newly discovered genomic features with the reference human genome.
• Comprehensive Annotation: Supports annotation of diverse genomic feature types including microRNAs (miRNAs), microarray primers or probes, Chip-on-Chip data, CpG islands, and SNPs.
• Versatile Data Handling: Handles multiple source types of genomic data to accommodate different experimental outputs.
• High-throughput Integration: Integrates feature mappings derived from high-throughput techniques and modern sequencing technologies into the reference framework.

Scientific Applications:

• Functional Genomics: Annotates new genomic elements to aid interpretation of gene regulation and expression.
• Genomic Variation Studies: Maps SNPs and other variants to facilitate analyses of genetic diversity and disease associations.
• Epigenetics Research: Provides annotation of CpG islands to support investigation of epigenetic modifications affecting gene activity.
• Transcriptomics: Maps miRNAs and microarray probes to enhance analysis of transcriptomic profiles and RNA-based regulation.

Methodology:

Automated alignment of genomic features to the human reference genome and annotation of feature types such as miRNAs, microarray probes, Chip-on-Chip data, CpG islands, and SNPs.