FoPGDB

FoPGDB provides a pangenome resource for the Fusarium oxysporum species complex (FOSC) that enables integrative analysis of genetic diversity and pathogenicity-related sequences across 35 high-quality FOSC genomes.

Key Features:

• Pangenome content: Integrates 35 high-quality genomes from the Fusarium oxysporum species complex (FOSC).
• Analytical approaches: Supports both gene-based and graph-based approaches for examining the pangenome.
• Effector curation: Includes extensive curation of putative effector sequences relevant to FOSC pathogenicity.
• Gene search: Provides gene search capabilities across the integrated FOSC genomes.
• Genomic variant exploration: Enables exploration of genomic variants within the pangenome.
• Functional enrichment: Offers tools for functional enrichment analysis of gene sets and variant-associated genes.

Scientific Applications:

• Genetic diversity analysis: Comparative analysis of gene presence–absence and sequence variation across 35 FOSC genomes.
• Pathogenicity and host–pathogen interaction studies: Investigation of putative effectors to study mechanisms of virulence and host specificity.
• Evolutionary and ecological research: Examination of pangenome composition to infer evolutionary relationships and ecological adaptations within FOSC.
• Disease management research: Identification of candidate genes and variants that can inform strategies for managing plant and human fusarioses.

Methodology:

Gene-based and graph-based pangenome analyses, curation of putative effector sequences, gene search, genomic variant exploration, and functional enrichment analysis.