FuncPEP

FuncPEP catalogs and annotates 112 experimentally validated and functionally characterized ncRNA-encoded peptides (ncPEPs) and their encoding ncRNA transcripts, emphasizing small open reading frames (smORFs) that frequently initiate at AUG start codons and terminate with atypical stop codons to support research into their roles in development, oncogenic transformation, and disease.

Key Features:

• Catalog of ncPEPs: Contains detailed annotations for 112 functional ncPEPs.
• ncRNA transcript annotation: Provides specific information about the ncRNA transcripts that encode these peptides.
• smORF and codon characterization: Documents small open reading frames (smORFs), noting initiation at AUG start codons and termination with atypical stop codons.
• Experimental validation: Compiles experimentally validated and functionally characterized ncPEPs.
• Functional and disease associations: Annotates reported roles in diverse cellular functions, deregulation in disease, and contribution to pathogenic processes including development and oncogenic transformation.
• Emphasis on ncPEPs as novel molecules: Focuses on ncRNA-encoded peptides (ncPEPs) as a distinct class of functional molecules.

Scientific Applications:

• Biological role investigation: Enables research into the biological significance of ncPEPs, including roles in development and oncogenic transformation.
• Disease mechanism studies: Supports studies of ncPEP deregulation in disease and their contribution to pathogenic processes.
• Medical research exploration: Facilitates exploration of potential applications in medicine.

Methodology:

Compilation and annotation of experimentally validated and functionally characterized ncPEPs and their encoding ncRNA transcripts, with explicit annotation of smORFs and codon features.