FungiExpresZ

FungiExpresZ enables analysis and visualization of high-throughput gene expression data to support comparative and functional studies in fungal biology and other organisms.

Key Features:

• Comprehensive Data Analysis Tools: Provides a suite of commonly used bioinformatics tools covering stages of gene expression analysis from preprocessing to visualization.
• Extensive RNA-seq Dataset Collection: Includes pre-processed public ribonucleic acid sequencing (RNA-seq) datasets for numerous fungal species, including human, plant, and insect pathogens.
• Integrated Data Analysis: Supports combined analysis of user-generated experimental data alongside publicly available RNA-seq datasets for comparative studies.
• Versatility Across Organisms: Tailored for fungal gene expression but applicable to gene expression data from any organism.

Scientific Applications:

• Fungal genomics and pathogenicity: Analysis of gene expression patterns to investigate genetic determinants of fungal biology and disease.
• Host–pathogen interaction studies: Comparative expression analyses to explore responses and interactions between fungi and their hosts.
• Virulence mechanism investigation: Identification and characterization of genes and pathways associated with fungal virulence.
• Antifungal resistance research: Examination of expression changes linked to resistance mechanisms against antifungal agents.
• Comparative and meta-analyses: Integration of user and public datasets to perform meta-analyses across experiments and species.

Methodology:

Implemented in R using the R-Shiny framework and incorporating pre-processed public RNA-seq datasets.