Funm6AViewer

Funm6AViewer analyzes context-specific N6-methyladenosine (m6A) RNA methylation to integrate differential m6A sites with differential gene expression and reveal functional gene interaction networks and prioritized genes mediating condition-specific regulation.

Key Features:

• Data Integration: Accepts differential RNA methylation and differential gene expression data, including inputs derived from MeRIP-seq.
• Distribution Examination: Analyzes the distribution of differential m6A sites to identify patterns and variations across conditions.
• Gene Prioritization: Prioritizes genes mediated by dynamic m6A methylation to highlight candidates likely involved in condition-specific regulatory processes.
• Network Characterization: Constructs and characterizes gene regulatory and interaction networks influenced by context-specific m6A modifications.
• Visualization Tools: Provides visual representations of gene interaction networks mediated by m6A methylation for exploratory analysis.

Scientific Applications:

• Epitranscriptome functional analysis: Identifies and explores the functional relevance of context-specific m6A modifications in the mRNA epitranscriptome.
• Regulatory network investigation: Reveals how dynamic m6A methylation shapes gene regulatory and interaction networks in diverse biological contexts.
• Disease and cellular process studies: Supports investigation of how reversible m6A RNA modifications influence cellular processes and disease mechanisms.

Methodology:

Integrates differential methylation data with gene expression profiles to construct and analyze functional gene interaction networks.