GABC

GABC maps aberrant noncoding events in the human genome associated with breast cancer to support multi-omics investigation of regulatory dysregulation.

Key Features:

• Comprehensive Noncoding Event Database: Catalogs 10,172 aberrant noncoding events including single nucleotide polymorphisms (SNPs), somatic mutations, long noncoding RNA, microRNA, DNA methylation, enhancers, and superenhancers.
• Multi-omics Integration: Integrates data across genome, transcriptome, and epigenome levels to relate noncoding events to molecular contexts.
• Detailed Biological Mechanism Descriptions: Provides curated descriptions of biological mechanisms, roles of functional regulators, genomic locations, and relationships for each event.

Scientific Applications:

• Reference resource: Serves as a curated catalog for researchers investigating noncoding genomic alterations in breast cancer.
• Mechanistic interpretation: Facilitates holistic analysis of how noncoding regions and regulatory dysregulation contribute to breast cancer pathology.
• Biomarker discovery: Aids identification of potential biomarkers for early diagnosis, prognosis, and personalized treatment strategies.
• Therapeutic research support: Supports efforts toward disease prevention and the development of targeted therapies by curating dysregulations related to breast cancer.

Methodology:

Curation and integration of multi-omics data from multiple sources to map noncoding events associated with breast cancer.