GAIA

GAIA catalogs G-quadruplexes (G4) in DNA and RNA across bacteria, archaea, and eukaryotes to provide genomic and transcriptomic G4 locations for comparative, functional, and therapeutic studies.

Key Features:

• Comprehensive Data Coverage: Contains G-quadruplex data across diverse species from bacteria, archaea, and eukaryotes to enable cross-kingdom comparisons.
• Transcriptome Data Availability: Reports locations of G4s within transcriptomes as well as genomic loci to support RNA-focused analyses.
• Prediction- and Analysis-derived Dataset: Integrates predictions and analyses of G-quadruplexes as the primary source of its entries.

Scientific Applications:

• Comparative Genomics and Evolutionary Studies: Enables analysis of evolutionary conservation and divergence of G4 structures across species and kingdoms.
• Functional Genomics and Transcriptomics: Supports investigations into G4 impacts on RNA stability, processing, and translation by providing transcriptome-localized G4s.
• Therapeutic Research: Facilitates identification of species- or locus-specific G4s relevant to drug targeting and disease-related studies.

Methodology:

Dataset entries are derived from predictions and analyses of G-quadruplexes across multiple species and integrated to report both genomic and transcriptomic G4 locations.