gcType

gcType provides a curated reference database of prokaryotic type strain genomes and linked phenotypic data to support genome-based taxonomy, phylogenetics, and functional analyses.


Key Features:

  • Extensive Genome Repository: Contains 1049 type strain genomes sequenced by the GCM 10K project and over 12,000 publicly available type strain genome sequences sourced from GenBank, curated with stringent quality control criteria and standardized annotation pipelines.
  • Integration with Phenotypic Data: Links genomic sequences with corresponding phenotypic information to enable combined genotypic–phenotypic analyses.
  • Advanced Search Capabilities: Supports cross-genome searches in multiple formats for comparative and exploratory genomic queries.
  • Data Analysis Pipelines: Provides data analysis pipelines tailored for genomic analyses and genome-based taxonomy.

Scientific Applications:

  • Microbial Taxonomy: Enables identification and genome-based classification of prokaryotic species using type strain reference genomes.
  • Phylogenetic Analysis: Supports reconstruction of phylogenetic relationships and evolutionary studies among prokaryotes.
  • Functional Genomics: Facilitates comparative genomic analyses to investigate genetic diversity and discover microbial functions.
  • Comparative Genomics: Allows cross-genome comparisons to identify conserved and variable genomic features across type strains.

Methodology:

Genomes comprise 1049 sequenced by the GCM 10K project and >12,000 from GenBank; sequences are curated with stringent quality control and processed through standardized data annotation pipelines, and are accessible via cross-genome search formats and data analysis pipelines for genomic analyses and genome-based taxonomy.

Topics

Details

Tool Type:
web application
Added:
1/18/2021
Last Updated:
11/24/2024

Operations

Publications

Shi W, Sun Q, Fan G, Hideaki S, Moriya O, Itoh T, Zhou Y, Cai M, Kim S, Lee J, Sedlacek I, Arahal DR, Lucena T, Kawasaki H, Evtushenko L, Weir BS, Alexander S, Dénes D, Tanasupawat S, Eurwilaichitr L, Ingsriswang S, Gomez-Gil B, Hazbón MH, Riojas MA, Suwannachart C, Yao S, Vandamme P, Peng F, Chen Z, Liu D, Sun X, Zhang X, Zhou Y, Meng Z, Wu L, Ma J. gcType: a high-quality type strain genome database for microbial phylogenetic and functional research. Nucleic Acids Research. 2020;49(D1):D694-D705. doi:10.1093/nar/gkaa957. PMID:33119759. PMCID:PMC7778895.

PMID: 33119759
PMCID: PMC7778895
Funding: - National Key Research Program of China: 2017YFC1201202, 2017YFD0400302, 2018YFD0400201 - Chinese Academy of Sciences: 153211KYSB, 201900211, KFZD-SW-219, XDA19050301, XXH13505, XXH13506 - National Science Foundation for Young Scientists of China: 31701157, 31801106 - European Social Fund: EFOP-3.6.3-VEKOP-16-2017-00005