Gene Expression Barcode

Gene Expression Barcode provides absolute measures of gene expression across 131 human and 89 mouse tissue types, including healthy and diseased samples, to determine which genes are expressed versus unexpressed.

Key Features:

• Absolute Expression Measures: Delivers absolute expressed/unexpressed calls for most annotated genes across 131 human and 89 mouse tissue types, covering healthy and diseased samples.
• Novel Algorithmic Approach: Employs an algorithm that uses public microarray data to build robust statistical models that convert microarray signals into expressed versus unexpressed calls.
• Comprehensive Data and Code: Provides processed expression data, raw data, curated annotations, and the code used to generate expression calls.

Scientific Applications:

• Cross-Tissue Differential Expression Analysis: Enables comparison of absolute gene activity across tissues to identify tissue-specific expression patterns.
• Homologous Gene Expression Studies: Supports comparison of conserved and divergent expression patterns between human and mouse for translational and evolutionary analyses.
• Disease Research: Facilitates investigation of pathological gene expression changes by including diseased tissue profiles for biomarker and target identification.

Methodology:

Builds robust statistical models from public microarray data in GEO and ArrayExpress to convert microarray signals into expressed/unexpressed calls.