Gene Set Builder

Gene Set Builder compiles, stores, exports, and shares gene sets to support multi-gene analyses of sequential, functional, and expressional relationships among genes.

Key Features:

• Support for Multiple Genomes: Supports 17 eukaryotic genomes from version 32 of the Ensembl database, encompassing species from yeast to human.
• User-Created Information Storage: Allows creation and storage of custom gene sets with personalized annotations.
• Export and Sharing Capabilities: Exports gene sets as lists of identifiers, tables, or sequences and enables sharing with specific users or public release.
• Integration with Analysis Tools: Provides a Perl API to enable direct connectivity with custom analysis tools.
• Database-driven Backend: Uses a database-driven system for storing and managing gene sets.

Scientific Applications:

• Multi-gene Analysis: Facilitates compilation and management of gene sets for analyses of sequential, functional, and expressional relationships among genes.
• Functional Genomics: Supports functional genomics investigations by organizing gene groups for downstream analysis and interpretation.
• Comparative Genomics: Enables cross-species comparative studies using gene sets drawn from the 17 supported eukaryotic genomes.
• Identifier Management: Reduces time required for finding and converting gene identifiers for downstream analyses.

Methodology:

Database-driven storage that leverages gene catalogs from Ensembl (version 32) and GeneLynx and exposes a Perl API for programmatic access.