GeneDB database

GeneDB provides a curated repository of genomic sequences and annotations for prokaryotic and eukaryotic pathogens and related organisms to support production-grade genome annotation and access to curated datasets.

Key Features:

• Integration of genome projects: Incorporates data from both completed and ongoing genome projects to aggregate diverse genomic information.
• Manual curation: Maintains high-quality curation with 17 of 41 datasets manually curated by biologists who incorporate relevant scientific literature.
• Database-driven annotation pipelines: Uses database-driven tools and pipelines to generate and update genome annotations.
• Support for assembly updates: Accommodates frequent assembly updates characteristic of pathogen genomics.
• Production and annotation database: Serves as a production-grade repository focused on predominantly pathogenic genomes.
• Comprehensive sequence and annotation access: Provides centralized access to genome sequences and their annotations.

Scientific Applications:

• Genomic studies: Enables analysis of genome sequences and annotations for pathogen biology research.
• Comparative genomics: Supports comparative analyses across strains and related organisms using aggregated sequence and annotation data.
• Functional genomics: Facilitates functional annotation and investigation of gene roles through curated annotations.
• Diagnostic and therapeutic development: Provides curated genomic information that informs development of diagnostics, therapeutics, and preventive strategies.

Methodology:

Employs database-driven tools and pipelines to process and update genomic sequence and annotation data, accommodating frequent assembly updates.