Geneimprint

GeneImprint catalogs imprinted genes and allele-specific parent-of-origin expression across multiple species to support analysis of imprinting and its roles in embryonic growth, behavioral development, and oncogenesis.

Key Features:

• Gene catalogue: Provides a catalogue of imprinted genes with annotated paternal or maternal allele-specific expression.
• Species inclusivity: Includes imprinting data from multiple species to enable cross-species comparison of imprinted loci.
• Functional insights: Annotates involvement of imprinted genes in embryonic development and behavioral regulation.
• Disease association: Links aberrant imprinting of genes to human genetic disorders and roles in carcinogenesis.

Scientific Applications:

• Developmental biology research: Enables investigation of imprinted genes' roles in embryonic growth and behavioral development.
• Cancer research: Supports study of imprinted genes functioning as oncogenes or tumor suppressors in cancer.
• Genetic disorder studies: Facilitates analysis of disorders linked to improper imprinting and their genetic bases.

Methodology:

Leverages epigenetic data to identify and catalog genes with parent-of-origin specific expression and integrates findings from genomic studies on imprinting marks and regulatory mechanisms.