GeneLab

GeneLab provides a curated repository and standardized processing infrastructure for genomic, transcriptomic, proteomic, and metabolomic datasets from biospecimens exposed to actual or simulated space environments to enable systems-biology investigations of molecular responses to space conditions.

Key Features:

• Spaceflight and space-relevant omics repository: Collects and curates genomic, transcriptomic, proteomic, and metabolomic datasets derived from biospecimens exposed to actual or simulated space environments.
• Standardized processing pipelines: Implements standardized pipelines for processing various omics data types to ensure consistency and comparability across assays.
• GeneLab Online Data Entry (GEODE) portal: Supports inclusion of companion non-omics assay data and structured metadata entry for datasets.
• Application Programming Interface (API): Provides an API to support visualization and retrieval of processed omics data.
• Data curation and standardization: Applies rigorous curation and standardization processes to maintain dataset accuracy and interoperability.

Scientific Applications:

• Systems-biology analyses: Enables investigation of molecular network responses to spaceflight and space-relevant stressors using integrated multi-omics data.
• Comparative multi-omics studies: Supports cross-omics comparisons among genomic, transcriptomic, proteomic, and metabolomic datasets to identify molecular signatures of space exposure.
• Spaceflight effects on human physiology: Facilitates molecular-level studies of how spaceflight impacts human health and physiology.

Methodology:

Standardized pipelines process various omics data types; datasets undergo rigorous curation and standardization; metadata are entered and structured via the GEODE portal; an API supports visualization and retrieval of processed omics data.