GeneTrail2

GeneTrail2 performs integrative gene set analysis of multi-omics datasets (transcriptomic, miRNomic, genomic, and proteomic) to identify enriched biological categories, signaling pathways, and candidate biomarkers.

Key Features:

• Integrated Multi-Omics Analysis: Supports simultaneous analysis of transcriptomic, miRNomic, genomic, and proteomic data to enable holistic gene set evaluations.
• Statistical Tools and Reference Sets: Implements multiple statistical tests for gene set analysis and provides numerous predefined reference sets to enhance result interpretation.
• Biological Categories: Includes a comprehensive collection of biological categories for detailed categorization and exploration of molecular signatures.

Scientific Applications:

• Disease mechanism elucidation: Enables elucidation of pathogenic mechanisms across diseases, including cancer, through integrative analysis of molecular datasets.
• Wilms tumor and nephroblastoma research: Has been used to investigate Wilms tumor pathogenesis, uncover signaling pathways in blastemal subtype tumors, and identify candidate biomarkers associated with adverse prognosis in nephroblastoma.

Methodology:

Performs gene set analysis using multiple statistical tests on integrated transcriptomic, miRNomic, genomic, and proteomic layers from the same samples.