Genin2

Genin2 predicts genotypes of clade 2.3.4.4b H5Nx viruses collected in Europe since October 2020 to identify epidemiologically relevant European genotypes.

Key Features:

• Speed and Efficiency: Performs rapid genotype prediction to support timely analysis during outbreaks.
• Targeted Genotype Identification: Identifies epidemiologically relevant European genotypes defined as those detected in at least three viruses from a minimum of two different countries.
• Comprehensive Database Utilization: Analyzes complete genomes from 1,956 European HPAI A(H5Nx) viruses to inform genotype assignments.

Scientific Applications:

• Epidemiological Tracking: Monitors spatiotemporal diffusion patterns of A(H5Nx) viruses within and across Europe during epidemic waves.
• Genetic Diversity Analysis: Characterizes high genetic diversity and frequent reassortment events among circulating viruses.
• Emergence of New Genotypes: Detects emergence of new genotypes, including those with gull-adapted genes that may enable exploitation of novel ecological niches.
• Public Health Surveillance: Supports identification of significant genotypes relevant for outbreak response and surveillance.
• Ecological Studies: Enables analysis of genotype adaptation to different hosts and environments.
• Predictive Modeling: Provides genotype data to inform models of future viral spread and evolution.

Methodology:

Performs genomic data analysis of complete genome sequences from 1,956 European HPAI A(H5Nx) viruses, focusing on spatiotemporal pattern analysis and identification of reassortment events to predict genotypes.