GenoCrypt beta

GenoCrypt beta identifies genetic relatives from high-throughput sequencing data while preserving participant privacy using cryptographic protocols.

Key Features:

• Privacy-Preserving: Employs cryptographic techniques to perform secure comparisons and relatedness tests on encrypted genomic data without requiring individuals to share their full genome with a third party.
• Comprehensive Variant Analysis: Uses both common and rare genetic variants to improve sensitivity for detecting familial relationships from sequencing data.
• Detection of Distant Relationships: Identifies relatedness up to fifth-degree cousins and detects cryptic relationships in datasets such as the 1000 Genomes Project.

Scientific Applications:

• Genealogical Research: Enables discovery of distant relatives from sequencing data while maintaining genomic confidentiality.
• Medical Genetics: Facilitates secure inference of familial connections relevant to analysis of hereditary conditions.
• Forensic Science: Supports establishment of genetic relationships in investigative contexts while protecting genomic privacy.

Methodology:

Performs relatedness tests on encrypted high-throughput sequencing data using cryptographic protocols and compares both common and rare genetic variants, demonstrated on datasets such as the 1000 Genomes Project.