genomeIntervals
genomeIntervals represents and manipulates genomic intervals in R to support interval-based analyses within the Bioconductor ecosystem for high-throughput genomics and molecular biology.
Key Features:
- Class definition for genomic intervals: Defines specialized R classes that encapsulate genomic interval coordinates and associated attributes for programmatic manipulation.
- Interoperability with Bioconductor packages: Integrates with the Bioconductor ecosystem, interoperating with over 934 packages for downstream bioinformatic and statistical analyses.
- Enhancement via 'girafe' package: Extensible through the 'girafe' package, which builds additional methods and functionality on the genomic-interval infrastructure.
- R-based implementation: Implements classes and functions within R's statistical programming environment for computational analysis of interval data.
Scientific Applications:
- Spatial interval analysis: Analyze genomic datasets where spatial relationships between genomic regions are critical, such as overlap and proximity queries.
- Interdisciplinary data integration: Provide a common data-structure for combining genomic, molecular biology, and bioinformatics data in collaborative research.
- Interval-based software development: Support development and deployment of scientific software that requires robust interval-centric computations for high-throughput analyses.
Methodology:
Implements classes and functions for genomic intervals in R and undergoes Bioconductor's formal initial review and continuous automated testing as stated.
Topics
Collections
Details
- License:
- Artistic-2.0
- Tool Type:
- command-line tool, library
- Operating Systems:
- Linux, Windows, Mac
- Programming Languages:
- R
- Added:
- 1/17/2017
- Last Updated:
- 11/25/2024
Operations
Publications
Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M. Orchestrating high-throughput genomic analysis with Bioconductor. Nature Methods. 2015;12(2):115-121. doi:10.1038/nmeth.3252. PMID:25633503. PMCID:PMC4509590.