Genomorama

Genomorama visualizes and analyzes multiple genomes to identify DNA hybridization sites and support design of probe- and PCR-based experimental assays.

Key Features:

• Interactive Genome Visualization: Displays multiple genomes with multi-scale visualization to support detailed genomic analysis and comparison.
• Genome Search Capabilities: Performs hybridization-based searches for specific DNA sequences to identify probe binding sites and potential PCR amplification regions.
• Support for Various Genome File Types: Parses and processes numerous genome file formats for analysis.
• Integration with NCBI Entrez Server: Queries and retrieves genomic sequences and related data directly from the NCBI Entrez server.

Scientific Applications:

• Experimental Assay Design: Identifies target genomic regions for designing targeted experimental assays.
• Probe and Primer Targeting: Locates potential DNA hybridization sites for probe binding and PCR primer design.
• Comparative Genomics: Facilitates comparison of multiple genomes through multi-scale visualization.
• Sequence Retrieval: Enables retrieval of reference sequences and genomic data from NCBI Entrez for downstream analyses.

Methodology:

Interactive multi-scale genome display; hybridization-based DNA sequence searching to locate probe binding sites and PCR regions; parsing of multiple genome file formats; querying and retrieval of sequences from the NCBI Entrez server.