GenOrigin

GenOrigin provides comprehensive age estimates for 9,102,113 protein-coding genes across 565 species to enable evolutionary and functional analyses of gene origination.

Key Features:

• Extensive Gene Age Data: Catalogs ages of 9,102,113 protein-coding genes from 565 species, including 82 bacteria, 57 protists, 134 fungi, 58 plants, 56 metazoa, and 178 vertebrates.
• Protein-family-based Dating: Derives gene age estimates using a protein-family-based pipeline that incorporates the Wagner parsimony algorithm.
• Data Integration and Standardization: Integrates gene age estimates from multiple studies and standardizes them into time ranges expressed in million years for consistent cross-study comparison.
• Comprehensive Annotations: Provides annotations for each gene including orthologs and paralogs and gene presence/absence across species trees with evolutionary timescales.

Scientific Applications:

• Dating of Novel Genes: Enables precise dating of recently originated genes to investigate their functional implications.
• Species-specific Gene Studies: Supports analysis of species-specific genes such as primate-specific genes to assess lineage-specific innovation.
• Genomic Network Integration: Facilitates studies of how newly originated genes integrate into genomic networks and contribute to novel phenotypes.
• Comparative Evolutionary Analyses: Supports comparative studies of gene origination and turnover across diverse taxa to explore patterns of biological diversity.

Methodology:

Gene age estimates are derived using a protein-family-based pipeline that incorporates the Wagner parsimony algorithm, with integration and standardization of age estimates into time ranges expressed in million years.