GeodesicSlicer

GeodesicSlicer enables MRI- and EEG-based target determination and rTMS dose correction for non-invasive brain stimulation (NIBS) research.

Key Features:

• Integration with 3D Slicer: Implemented as an extension of 3D Slicer for medical image processing and three-dimensional visualization.
• Customizable Target Determination: Determines cortical stimulation targets using functional and anatomical imaging data for NIBS therapies such as repetitive Transcranial Magnetic Stimulation (rTMS).
• Electrode Positioning and Dose Adjustment: Maps electrode positions in the EEG 10-20 system and calculates correction factors to adjust rTMS dosages.
• Triangulation-Based MRI-Guided Method: Implements a triangulation-based MRI-guided method for reproducible positioning of TMS coils without relying on neuronavigation systems.

Scientific Applications:

• NIBS Target Localization: Localizing cortical stimulation targets for studies of non-invasive brain stimulation, including rTMS.
• rTMS Dosage Calibration: Computing subject-specific correction factors to adjust rTMS dose for therapeutic and research protocols.
• TMS Coil Positioning without Neuronavigation: Enabling reproducible TMS coil placement using MRI-based triangulation when neuronavigation systems are not used.

Methodology:

Implemented as a 3D Slicer extension; uses anatomical and functional MRI for target determination, maps EEG 10-20 electrode positions for localization, calculates correction factors for rTMS dosage, and applies a triangulation-based MRI-guided method for TMS coil positioning.