Geonomics

Geonomics performs forward-time, individual-based, spatially explicit landscape genomic simulations to investigate drivers of spatial patterns of genomic diversity.


Key Features:

  • Forward-time, individual-based simulations: Implements forward-time, individual-based simulation frameworks for modeling evolutionary dynamics.
  • Spatially explicit modeling with full pedigrees: Represents full spatial pedigrees to capture spatially explicit ancestry and dispersal effects on genomic variation.
  • Python implementation: Implemented in Python, enabling customization and extensibility through code-level interfaces.
  • Validation against population genetics models: Validated against classic models in population genetics to ensure expected behavior.
  • Complex scenario simulation: Supports simulations of polygenic selection, multiple trait selection, complex landscapes, and nonstationary environmental changes.
  • Performance scaling: Runtime scales primarily with landscape raster size, and memory usage scales with maximum population size and recombination rate.
  • Model approximations: Approximates recombination and movement processes within its simulation models.

Scientific Applications:

  • Landscape-genetic inference: Assess the impact of landscape features on genetic diversity and spatial genetic structure.
  • Environmental change response: Explore evolutionary responses to nonstationary environmental changes over time.
  • Population genetic processes: Investigate the roles of genetic drift, gene flow, and selection pressures within spatially structured populations.

Methodology:

Uses forward-time, individual-based, spatially explicit simulations with full spatial pedigrees implemented in Python; validated against classic population genetics models; includes approximations of recombination and movement, with performance influenced by landscape raster size, maximum population size, and recombination rate.

Topics

Details

License:
MIT
Tool Type:
library
Operating Systems:
Mac, Linux, Windows
Programming Languages:
Python
Added:
11/8/2021
Last Updated:
11/8/2021

Operations

Publications

Terasaki Hart DE, Bishop AP, Wang IJ. Geonomics: Forward-Time, Spatially Explicit, and Arbitrarily Complex Landscape Genomic Simulations. Molecular Biology and Evolution. 2021;38(10):4634-4646. doi:10.1093/molbev/msab175. PMID:34117771. PMCID:PMC8476160.

PMID: 34117771
PMCID: PMC8476160
Funding: - National Science Foundation: DEB-1845682