Geonomics
Geonomics performs forward-time, individual-based, spatially explicit landscape genomic simulations to investigate drivers of spatial patterns of genomic diversity.
Key Features:
- Forward-time, individual-based simulations: Implements forward-time, individual-based simulation frameworks for modeling evolutionary dynamics.
- Spatially explicit modeling with full pedigrees: Represents full spatial pedigrees to capture spatially explicit ancestry and dispersal effects on genomic variation.
- Python implementation: Implemented in Python, enabling customization and extensibility through code-level interfaces.
- Validation against population genetics models: Validated against classic models in population genetics to ensure expected behavior.
- Complex scenario simulation: Supports simulations of polygenic selection, multiple trait selection, complex landscapes, and nonstationary environmental changes.
- Performance scaling: Runtime scales primarily with landscape raster size, and memory usage scales with maximum population size and recombination rate.
- Model approximations: Approximates recombination and movement processes within its simulation models.
Scientific Applications:
- Landscape-genetic inference: Assess the impact of landscape features on genetic diversity and spatial genetic structure.
- Environmental change response: Explore evolutionary responses to nonstationary environmental changes over time.
- Population genetic processes: Investigate the roles of genetic drift, gene flow, and selection pressures within spatially structured populations.
Methodology:
Uses forward-time, individual-based, spatially explicit simulations with full spatial pedigrees implemented in Python; validated against classic population genetics models; includes approximations of recombination and movement, with performance influenced by landscape raster size, maximum population size, and recombination rate.
Topics
Details
- License:
- MIT
- Tool Type:
- library
- Operating Systems:
- Mac, Linux, Windows
- Programming Languages:
- Python
- Added:
- 11/8/2021
- Last Updated:
- 11/8/2021
Operations
Publications
Terasaki Hart DE, Bishop AP, Wang IJ. Geonomics: Forward-Time, Spatially Explicit, and Arbitrarily Complex Landscape Genomic Simulations. Molecular Biology and Evolution. 2021;38(10):4634-4646. doi:10.1093/molbev/msab175. PMID:34117771. PMCID:PMC8476160.