GIMICA

GIMICA catalogs host genetic and immune factors that influence human microbiota composition to enable analysis of host–microbiota interactions.

Key Features:

• Integration of Host Genetic Factors (HGFs): Includes data on 2851 host genetic factors that modulate expression of 370 microbes across nine human body sites, comprising 1368 single nucleotide polymorphisms (SNPs), 186 copy number variations (CNVs), and 1297 non-coding RNAs.
• Inclusion of Host Immune Factors (HIFs): Provides information on 549 host immune factors that regulate the abundance of 455 microbes, categorized into 126 lymphocytes and phagocytes, 387 immune proteins, and 36 immune pathways.
• Joint host–microbe–environment consideration: Supports collective consideration of HGFs and HIFs and their interactions with environmental influences.
• Comprehensive microbial coverage: Contains records compiled from 4257 microbes confirmed to inhabit nine distinct human body sites.

Scientific Applications:

• Personalized Medicine: Enables investigation of individual genetic and immune profiles in relation to microbiota composition for personalized health insights.
• Microbiota Research: Facilitates studies on the role of host genetic and immune factors in microbiota composition and function across different body sites.
• Disease Mechanism Exploration: Aids identification of links among host genetic factors, immune factors, microbial communities, and disease states.

Methodology:

Construction involved collection and integration of data from 4257 microbes confirmed to inhabit nine distinct human body sites.