Glaucoma-TrEl

Glaucoma-TrEl catalogs interactions between trace elements and protein-coding genes implicated in glaucoma to support analysis of their roles in glaucoma pathophysiology.

Key Features:

• Comprehensive gene–trace element interactions: The database contains interaction data for 437 unique genes and eight distinct trace elements associated with glaucoma.
• Pathway association analysis: Genes that interact with trace elements are associated with known glaucoma-related pathways to reveal potential mechanistic links.
• Multi-element interaction mapping: The resource identifies and records genes that interact with multiple trace elements.
• Data compilation and analysis: Curated interaction data were compiled and analyzed to identify significant gene–trace element interactions.

Scientific Applications:

• Mechanistic investigation: Investigation of how trace elements influence gene function and glaucoma-related pathways.
• Target identification: Support for identifying candidate genes and pathways for therapeutic targeting based on element–gene interactions.
• Hypothesis generation: Generation of evidence-based hypotheses linking environmental trace element exposure to genetic factors in glaucoma.

Methodology:

Interaction data for trace elements and protein-coding genes linked to glaucoma were compiled, analyzed to identify significant gene–trace element interactions, and mapped to known glaucoma-related pathways.