GLEANER

GLEANER integrates and visualizes multiomics data (transcriptomes, DNA methylomes, chromatin accessibility, and histone modifications H3K4me3, H3K27me3, and H3K9me3) to analyze transcriptional and epigenetic dynamics across human and mouse germline cycles.

Key Features:

• Comprehensive multiomics integration: Aggregates transcriptome profiles, DNA methylomes, chromatin accessibility landscapes, and histone modification data (H3K4me3, H3K27me3, H3K9me3) for combined analysis.
• Stage-resolved analysis: Enables examination of transcriptional and epigenetic characteristics across different stages of the mammalian germline cycle.
• Dynamic trend visualization: Depicts continuous temporal trends in gene expression and epigenetic modifications throughout the germline cycle.
• Gene-specific integrative analysis: Provides integrative transcriptional and epigenetic feature summaries for individual genes and identifies genes with correlated transcriptional changes.

Scientific Applications:

• Regulatory mechanism analysis: Facilitates study of genetic and epigenetic regulatory mechanisms governing germline development in mammals.
• Transgenerational epigenetic studies: Supports investigation of how epigenetic modifications and transcriptional states may contribute to information transmission across generations.
• Hypothesis generation for cell potency and differentiation: Aids formulation of hypotheses on regulatory pathways influencing cell potency and differentiation during germline cycles.

Methodology:

Aggregates existing multiomic datasets related to the mammalian germline cycle and applies integrative correlation analyses between gene expression and epigenetic modifications.