GlobPlot

GlobPlot predicts regions of globularity and intrinsic disorder in protein sequences to inform structural and functional analysis.

Key Features:

• Globularity and Disorder Prediction: Visualizes the tendency towards globularity or disorder across a protein sequence, highlighting non-globular segments that may contain short linear peptide motifs such as SH3-binding sites.
• Identification of Unstructured Regions: Detects unstructured or disordered regions that frequently harbor functional linear motifs.
• Domain Hunting and Analysis: Identifies inter-domain segments containing linear motifs and ordered regions that do not correspond to recognized domains, and pinpoints additional N- or C-terminal segments within known domains.
• Proteome Analysis (GlobPipe): Includes the GlobPipe pipeline interface for whole-proteome analysis.
• Generic Graphical Display Infrastructure: Provides a graphical display infrastructure for plotting any sequence propensity across protein sequences.

Scientific Applications:

• Construct Design for Structural Biology: Assists design of constructs corresponding to globular protein regions for biochemical and structural studies.
• Modeling Protein Structure and Function: Provides insights into ordered and disordered regions to support more accurate models of protein structure and function.

Methodology:

Visualizes sequence-wise propensities for globularity and disorder, provides a graphical plotting infrastructure, and offers the GlobPipe pipeline for whole-proteome analyses.