GLYCO

GLYCO quantifies glycan shielding on glycosylated protein surfaces at atomistic resolution to characterize glycan distribution and density for structural biology and immunological studies.

Key Features:

• Atomistic Analysis: Quantifies glycan coverage on protein surfaces at atomistic resolution.
• Versatile Input Compatibility: Processes single or multiple coordinate files including outputs from molecular dynamics simulations and nuclear magnetic resonance (NMR) structure determinations.
• Dynamic Analysis Capability: Enables analysis of glycan dynamics over time by processing multiple coordinate files.
• Comprehensive Surface Insights: Provides whole-surface and region-specific quantification of glycan distribution to identify glycan-dense and glycan-sparse areas.

Scientific Applications:

• Protein Folding: Relates glycan distribution to protein stability and conformation.
• Cell-Cell Interactions: Elucidates roles of surface glycans in mediating cell–cell interactions by quantifying coverage.
• Immune Response Modulation: Investigates how glycan shielding affects antigenicity and immune evasion mechanisms.

Methodology:

Processes coordinate files (single structures or multiple frames) from structural determination techniques such as molecular dynamics simulations and NMR, and computes the extent of glycan coverage on protein surfaces for static and dynamic analyses.