Glycosciences

Glycosciences provides centralized cross-linking, search, and retrieval of glycan structures and associated data—including references, composition, spatial structures, experimental and estimated Nuclear Magnetic Resonance (NMR) shifts, theoretically calculated fragments, and Protein Database (PDB) entries—to support glycomics research.

Key Features:

• Structure-based cross-linking: Integrates glycan-related datasets from multiple resources to enable correlation of structures and associated data across studies and databases.
• Advanced retrieval options: Supports structure-oriented searches by exact structure, substructure, motif, composition, and sugar components.
• Diverse data types: Includes references and literature citations, composition data, spatial structures, Nuclear Magnetic Resonance (NMR) shifts (experimental and estimated), theoretically calculated fragments, and Protein Database (PDB) entries, with example entries such as Man(3).

Scientific Applications:

• Comparative glycomics: Study glycan structures across different species, organs, tissues, or cells.
• Method development: Support development of new methodologies for glycan analysis and characterization.
• Functional glycomics: Enable investigation of the biological roles and functions of glycans.

Methodology:

Standardized framework for data deposition and retrieval using a universally accepted exchange format and a common software interface.