GlyCosmos

GlyCosmos integrates glycan-related data from public glycoscience repositories and 'omics databases and links glycan structures to chemical, genetic, proteomic, pathway, and disease information to support integrative glycoscience research.

Key Features:

• Data Integration: Amalgamates glycan structures and associated metadata from GlyTouCan, GlycoPOST, UniCarb-DR, and other glycan-associated datasets derived from diverse 'omics databases.
• Cross-linking with PubChem: Establishes links between glycan entries and PubChem (National Center for Biotechnology Information) to connect chemical, genetic, proteomic, and pathway data.
• Entity Coverage: Provides structured information on glycogenes, glycoproteins, lectins, pathways, and glycan-related diseases.

Scientific Applications:

• Glycan structure research: Supports investigation and annotation of glycan structures using integrated structural and repository data.
• Functional and pathway analysis: Enables analysis of glycans in biological pathways and their roles through links to pathway and proteomic information.
• Disease association studies: Facilitates exploration of glycan-related disease associations by linking glycan data to disease and genetic information.
• Integrative multi-omics analyses: Allows cross-referencing of chemical, genetic, proteomic, and pathway datasets for integrated glycoscience investigations.

Methodology:

Aggregates and cross-links datasets from GlyTouCan, GlycoPOST, UniCarb-DR and other omics sources and establishes mappings to PubChem for chemical, genetic, proteomic, and pathway connections.