GlycoViewer

GlycoViewer visualizes and summarizes glycan structures to enable comparison and analysis of glycomes across proteins, cells, tissues, and organisms.

Key Features:

• Input Flexibility: Accepts glycan structures in IUPAC format or via a sugar structure builder.
• Detailed Graphic Output: Generates color-coded, icon-based graphics showing core structure shapes, chain nature and length, and terminal epitope types, following Consortium for Functional Glycomics (CFG) recommendations.
• Scalability: Processes and summarizes up to hundreds of glycan structures in a single figure.
• Comparative Analysis: Provides high-level comparative views of glycans derived from proteins, cells, tissues, or whole organisms.

Scientific Applications:

• Proteomic Glycan Analysis: Summarizes glycans associated with specific proteins to support analysis of protein–glycan interactions.
• Cellular and Tissue Glycome Studies: Visualizes glycan profiles at the cellular or tissue level to study cell surface glycosylation patterns.
• Organismal Glycomics: Analyzes glycans from whole organisms to provide comprehensive organismal glycome overviews.
• Disease Biomarker Discovery: Enables comparison of normal and disease-associated glycans within the human glycoproteome to aid biomarker identification and investigation of disease mechanisms.

Methodology:

Categorizes glycans based on structural features such as core shapes, chain characteristics, and terminal epitopes to generate summarized graphical representations.