gOrth

gOrth performs functional enrichment analysis of gene lists and translates gene identifiers to map functions, pathways, and homologs for interpretation of high-throughput biological data.

Key Features:

• Functional Enrichment Analysis: Analyzes flat and ranked gene lists to identify statistically significant Gene Ontology (GO) terms, pathways, and related gene function annotations.
• Gene Identifier Translation: Translates hundreds of gene identifiers across species and maps genes to homologous counterparts in target organisms.
• Extensive Species Support: Supports 213 species, including mammals, other vertebrates, plants, insects, and fungi.
• Timely Data Synchronization: Synchronizes genome and pathway information with the Ensembl database on a quarterly schedule.
• Novel Functional Datasets (2016): Incorporates transcription factor binding site predictions, Mendelian disease annotations, protein expression and complex information, and gene mappings of human genetic polymorphisms.

Scientific Applications:

• High-throughput data interpretation: Provides functional context for gene lists from RNA sequencing, ChIP-seq, and other genomic studies.
• Disease and target discovery: Supports investigation of disease mechanisms and identification of potential therapeutic targets through annotation and enrichment results.

Methodology:

Performs statistical enrichment analysis on flat and ranked gene lists; translates gene identifiers and maps homologs; synchronizes data with Ensembl quarterly; applies transcription factor binding site prediction, Mendelian disease annotation mapping, integration of protein expression and complex information, and mapping of human genetic polymorphisms.