GPCR SARfari BLAST Search

GPCR SARfari BLAST Search performs BLAST searches against GPCR domains in the GPCR SARfari database to identify homologous receptor sequences and support analysis of sequence variation relevant to ADME processes.

Key Features:

• Data Integration: Integrates publicly available drug-disposition gene and ADME-related data, including interactions between small molecules and ADME proteins, focused on GPCR domains.
• Comparative Analyses: Enables comparative protein sequence analyses across species, including human orthologues, and provides Single Nucleotide Polymorphism (SNP) and tissue distribution information.
• Predictive Tools: Includes in silico models that predict interactions between novel compounds and ADME-relevant protein targets.
• Visualizations: Produces data mining outputs and visualizations for interpreting GPCR domain datasets and small-molecule interaction data.

Scientific Applications:

• Drug Metabolism Research: Analyze interactions of small molecules with ADME proteins to investigate drug metabolism mechanisms.
• Pharmacokinetics (PK) Studies: Support analyses of absorption, distribution, metabolism, and excretion properties by integrating PK-relevant sequence and interaction data.
• Pre-clinical Model Development: Compare ADME-related protein sequences across species to inform selection and interpretation of pre-clinical models and human relevance.

Methodology:

The tool uses BLAST (Basic Local Alignment Search Tool) to search GPCR domain sequences in the GPCR SARfari database to identify homologous sequences and infer potential functional similarities.