GRETTA

GRETTA performs in silico genetic interaction screening and essentiality network analyses as an R package to map genetic interactions and identify vulnerabilities and gene functions in human cell lines with specific genetic alterations by leveraging publicly available datasets.

Key Features:

• In Silico Genetic Interaction Screening: Maps genetic interaction networks in human cell lines using computational analysis of publicly available datasets.
• Essentiality Network Analysis: Constructs essentiality networks to reveal gene dependencies, vulnerabilities, and to associate novel functions to genes.
• R Package Implementation: Implements analyses and network mapping within an R package environment.
• Public Data Integration: Leverages publicly available datasets to perform interaction and essentiality analyses on genetically altered cell lines.

Scientific Applications:

• Genetic Interaction Discovery: Identifies genetic interactions and network relationships among genes in human cell lines with specific alterations.
• Therapeutic Target Identification: Reveals genetic vulnerabilities that can inform potential therapeutic targets specific to genetic alterations.
• Functional Gene Annotation: Supports assignment of novel functions to genes through essentiality network analysis.

Methodology:

Performs in silico genetic interaction screens and essentiality network analyses within R by analyzing publicly available datasets.