GTExVisualizer

GTExVisualizer enables age- and sex-stratified analysis and visualization of GTEx transcriptomic data across tissues to investigate molecular changes associated with ageing and sex.

Key Features:

• Enhanced Query Capabilities: Retrieves GTEx expression data for specified genes across tissues segmented by age groups and sex.
• Graphical Representation and Analysis: Generates plots that represent gene expression patterns across sex and age categories.
• Network-Based Modules Integration: Analyzes genes within interaction contexts using network-based modules and protein interaction networks.
• Plot-Based and Network Reporting: Exports analysis results as plots and as gene/network representations.
• Statistical Analysis Tools: Performs statistical comparisons to highlight expression differences among sex and age groups.

Scientific Applications:

• Ageing transcriptomics: Investigates how gene expression changes with ageing across multiple tissues using GTEx data.
• Sex-specific expression analysis: Detects sex-related differences in transcriptomic profiles across tissues and age groups.
• Cross-tissue comparative studies: Compares expression patterns of genes across different tissues stratified by age and sex.
• Network-based pathway investigation: Explores gene interaction networks to study molecular pathways affected by ageing and sex.
• Biomarker and target identification: Supports identification of age- or sex-associated molecular signatures relevant to age-related diseases and therapeutic targets.

Methodology:

Operates on the GTEx transcriptomics dataset annotated with tissue type, gender and age metadata, and performs query-based data retrieval, visualization, statistical comparisons across sex and age groups, and network-module analyses.