IUPHAR BPS Guide to PHARMACOLOGY

IUPHAR BPS Guide to PHARMACOLOGY provides a curated, peer-reviewed repository of pharmacological, chemical, genetic, functional, and pathophysiological data on approved and experimental drug targets and their ligands to support analysis of drug–target interactions.

Key Features:

• Data integration: Integrates information from the IUPHAR Database (IUPHAR-DB) and the BPS Guide to Receptors and Channels (GRAC) into a single compilation of target properties.
• Expert curation: Entries are manually curated by a global network of expert contributors and presented as a peer-reviewed compilation.
• Ligand coverage: Contains detailed records for approximately 6,000 small molecule and peptide ligands.
• Data types: Includes pharmacological, chemical, genetic, functional, and pathophysiological annotations for targets and ligands.
• Chemical and sequence annotation: Ligands are annotated with manually curated two-dimensional chemical structures or amino acid sequences and standardized nomenclature.
• Cross-references: Provides links to external databases including ChEMBL, DrugBank, Ensembl, PubChem, UniProt, and PubMed.
• Target scope: Covers both approved and experimental drug targets and aims to expand coverage to targets associated with approved drugs and candidate targets.

Scientific Applications:

• Authoritative reference: Serves as a reference source for researchers requiring curated target and ligand properties.
• Drug–target interaction analysis: Supports analysis of drug–target interactions using curated bioactivity and structural annotations.
• Cheminformatics and chemical biology: Enables linking of two-dimensional chemical structures to biological targets and bioactivity data for cheminformatics studies.
• Education and training: Provides concise overviews and in-depth information on selected targets for teaching pharmacological principles.

Methodology:

Information is integrated from IUPHAR-DB and GRAC, manually curated by experts, annotated with two-dimensional chemical structures or amino acid sequences and standardized nomenclature, and cross-referenced to ChEMBL, DrugBank, Ensembl, PubChem, UniProt, and PubMed.