gutMEGA

gutMEGA curates and hosts quantitative metagenomic datasets of the human gut microbiota to enable analysis of temporal and spatial variations and associations with phenotypes and diseases.

Key Features:

• Quantitative dataset corpus: Integrates 59,132 quantification events derived from metagenomic studies of the human gut.
• Taxonomic coverage: Contains data for 6,457 taxa categorized at seven taxonomic levels: kingdom, phylum, class, order, family, genus, and species.
• Experimental condition annotation: Includes annotations for 776 experimental conditions spanning diverse physiological and pathological states.
• Relative abundance measurements: Provides relative abundance data for intestinal microbes linked to specific phenotypes.
• Compositional and phenotypic metadata: Consolidates composition and phenotypic characteristics of gut microbiota across integrated studies.
• Temporal and spatial variation data: Supports exploration of temporal and spatial variation in gut microbial communities.

Scientific Applications:

• Microbiota–health interaction studies: Investigating interactions between gut microbiota and human physiological homeostasis.
• Disease association analysis: Studying microbial contributions to disease emergence, including associations with cancers and mental health disorders.
• Phenotype association studies: Associating microbial relative abundances with host phenotypes across integrated datasets.
• Exploration of spatiotemporal dynamics: Analyzing temporal and spatial variations of gut microbial communities under diverse conditions.

Methodology:

Curation and integration of published metagenomic quantification events into a standardized database annotated by taxonomic level (kingdom to species), experimental condition (776 conditions), and relative abundance measurements (59,132 events across 6,457 taxa).