gwasfilter

gwasfilter filters GWAS records from the GWAS Catalog Website using an R script to select studies based on explicit criteria such as replication status, sample size, and study population ethnicity to standardize study selection for genetic epidemiology analyses.

Key Features:

• Implementation: R script that encapsulates established selection principles into five self-defined functions.
• Filter criteria: Supports filtering by replication status, sample size, study population ethnicity, and other study-level conditions.
• Performance: Capable of filtering GWASs for a single trait in under one second.
• Data source: Operates on GWAS data sourced from the GWAS Catalog Website.

Scientific Applications:

• Meta-analyses: Selects GWAS studies that meet explicit inclusion criteria for pooled genetic analyses.
• Systematic reviews: Produces standardized study sets for systematic reviews in genetic epidemiology.
• Study quality assessment: Identifies GWAS records meeting replication and sample-size thresholds for downstream analyses.

Methodology:

R script applies five self-defined functions that encode selection principles derived from previous studies to filter GWAS Catalog entries.