gwasrapidd

gwasrapidd provides programmatic access to the National Human Genome Research Institute's GWAS Catalog via its REST API, exposing GWAS Catalog data in R for retrieval, filtering, and downstream analysis.

Key Features:

• Programmatic access via REST API: Implements an R client to query and download data from the GWAS Catalog REST API.
• Data retrieval and filtering: Provides functions to retrieve specific GWAS Catalog datasets and apply filters to select data by traits, loci, or study criteria.
• Integration with bioinformatics tools: Exposes GWAS Catalog data as R objects suitable for use with other bioinformatics analysis packages and workflows.

Scientific Applications:

• Identification of genetic risk factors: Enables exploration of associations between genetic variants and diseases or traits using GWAS Catalog records.
• Functional genomics studies: Supports investigation of biological mechanisms underlying GWAS-identified loci and the functional characterization of risk loci.
• Data integration and meta-analyses: Facilitates aggregation and comparison of GWAS Catalog data across studies to support meta-analyses and cross-study analyses.

Methodology:

Retrieves GWAS Catalog data by querying the GWAS Catalog REST API and exposes functions in R to access, filter, and manipulate the retrieved datasets.