GWIDD

GWIDD provides a repository of experimental and docking-derived three-dimensional structures of protein-protein interactions across diverse organisms to support genome-scale structural interaction studies.

Key Features:

• Extensive database coverage: As of August 2009, GWIDD encompasses over 25,559 experimental and modeled three-dimensional protein structures spanning 771 different organisms, from viruses to humans.
• Integration of experimental and computational data: Merges experimental structures with models obtained through docking techniques to represent protein-protein interactions at the molecular level.
• PDB-formatted outputs: Provides search results in PDB format containing atomic coordinates for experimental and modeled protein-protein complexes.

Scientific Applications:

• Structural biology: Enables investigation of protein-protein interface geometry and interaction mechanisms using experimental and docking-derived 3D structures.
• Molecular biology: Supports elucidation of the molecular basis of biological processes through structural interaction data.
• Bioinformatics: Facilitates genome-wide structural interaction studies, comparative analyses, and evolutionary analyses across species.
• Biomedical research: Informs applied biomedical investigations that require structural models of protein-protein complexes.

Methodology:

Systematically collects and organizes protein interaction data by combining experimental findings with computational docking models.